Abstract:

The diversity of marine microorganisms and fungi has led to various chemical extracts, some of which have specific medicinal values. Norcyclocitrinoic acid A extracted from the deep-sea fungus Rhizopus sp. W23 has a unique tetracyclic steroid structure, which makes it possible to have anti-osteoporotic activity. This article opens up a whole new way of thinking about the pure chemical synthesis of Norcyclocitrinoic acid A. A very detailed synthetic pathway is explained in this article. In addition, a sugar-like structure and a Vitamin C-like structure were found in the synthesis, providing a basic idea for the future synthesis of more fungal extracts. Furthermore, the article suggests many directions for further research and experimentation.